Systemic Antibiotic and Nonsteroidal Anti-Inflammatory Drug Treatment Decreases the Level of Endogenous Angiogenic Vascular Endothelial Growth Factor in Inflamed Human Periapical Tissues

Vascular endothelial growth factor (VEGF)-induced angiogenesis contributes to inflammatory bone resorption in humans. Widely documented antagonists include antibiotics and non-steroidal anti-inflammatory drugs (NSAIDs). The purpose of this study was investigate the effect these on proangiogenic VEGF levels periradicular lesions. Periapical tissue biopsies were obtained from 42 patients with chronic periapical periodontitis. measured using a commercial ELISA kit divided into groups according treatment: no (control group, n = 25), NSAIDs (n 7), 5), 5). Reverse transcriptase (RT) reaction performed all samples under analysis. Presence VEGFA VEGFB gene expression assessed reverse-transcription-polymerase chain (RT-PCR). analysis indicated that average treated (6.097 ± 1.930 ng/mL), (5.661 2.395 (7.142 2.601 ng/mL) significantly lower than control (10.432 4.257 ng/mL, ANOVA p 0.008). RT-PCR did not reveal any samples. found 26 (69.1%). use or exacerbated periodontitis decreases tissues. Pharmacotherapy may minimize effects apical progression way.